I have tried 4 different meds

That sounds incredibly frustrating, , that with four different medications the side effects have been so bad that you can't work. It sounds like you might be in good contact with your doctor, though, if you're going to start trying something different, the simponi? Hopefully some of our community members can share their experiences with Simponi with you, but in the meantime I wanted to share a couple of stories with you. This one the member mentions having good experience with Simponi, https://psoriatic-arthritis.com/stories/management-plan. As well as this one, https://psoriatic-arthritis.com/stories/new-approach. And this forum includes some people's experiences with side effects on Simponi, https://psoriatic-arthritis.com/forums/simponi-aria-infusion. Of course, it's hard to know how a medication will impact a person as it can be different for each person, but hopefully some of the information will be helpful for you. -- Warmly, Christine (Team Member)