What Types of Medicines Are Used to Treat Psoriatic Arthritis?

Reviewed by: HU Medical Review Board | Last reviewed: August 2022 | Last updated: March 2023

There are several kinds of medicines used to treat psoriatic arthritis (PsA). They target different things in the body to help reduce inflammation and other PsA symptoms. Inflammation can lead to joint damage and long-term disability, so it is important to treat it.1

Treatments for PsA fall into several categories, including:1,2

  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Corticosteroids
  • Traditional disease-modifying anti-rheumatic drugs (DMARDs)
  • Biologic DMARDs
  • Biosimilars
  • Target-specific DMARDs
  • Other drugs

What are NSAIDs?

NSAIDs are commonly used pain medicines that can help decrease inflammation. They can be an effective treatment for mild PsA.1,2

Some NSAIDs are available over the counter. Others are available only with a prescription. NSAIDs include:1

  • Aspirin
  • Ibuprofen
  • Naproxen
  • Other generic and brand-name drugs

Most people tolerate NSAIDs well, but side effects are possible.1,2

What are corticosteroids?

Corticosteroids are also called glucocorticoids or steroids. They are drugs that help reduce inflammation in the body. They are used to treat PsA as well as other diseases.1,3

For people with PsA, corticosteroids are taken by mouth or injected into affected joints. These drugs tend to have many side effects, and some experts do not favor this form of treatment. Talk with your doctor about what is best for you.1,3

What are traditional DMARDs?

Traditional DMARDs are drugs that slow or stop inflammation. They are usually taken as a pill. Traditional DMARDs include:1,4,5

  • Methotrexate
  • Azulfidine® (sulfasalazine)
  • Arava® (leflunomide)
  • Imuran® (azathioprine)
  • Antimalarial drugs such as Plaquenil® (hydroxychloroquine)

What are biologic DMARDs?

Biologic DMARDs are drugs made from living cells. These cells can come from parts of the blood, proteins, viruses, or tissue. This process creates drugs that can prevent, treat, and cure disease.5

In people with PsA, biologic DMARDs reduce the immune system’s response. They do this by interfering with specific proteins. In this way, they regulate the inflammatory responses that cause PsA symptoms.5

Biologic DMARDs target proteins such as tumor necrosis factor (TNF) and various interleukins (IL). They are usually given as an injection or infusion. Examples of biologic DMARDs include:1,5

  • Cimzia® (certolizumab pegol)
  • Cosentyx® (secukinumab)
  • Enbrel® (etanercept)
  • Humira® (adalimumab)
  • Orencia® (abatacept)
  • Remicade® (infliximab)
  • Simponi® (golimumab)
  • Simponi Aria® (golimumab)
  • Stelara® (ustekinumab)
  • Taltz® (ixekizumab)
  • Tremfya® (guselkumab)

What are biosimilars?

Biosimilars are drugs that are similar to an already-approved biologic product. Like biologics, biosimilars are made from living organisms. They have human-made proteins that mimic certain functions in human genes or cells. Examples of biosimilars used to treat PsA include:6

  • Amjevita™ (adalimumab-atto)
  • Cyltezo® (adalimumab-adbm)
  • Erelzi™ (etanercept-szzs)
  • Inflectra® (infliximab-dyyb)
  • Ixifi™ (infliximab-qbtx)
  • Renflexis™ (infliximab-abda)

What are target-specific DMARDs?

Target-specific DMARDs work by targeting certain enzymes to help reduce the inflammatory response that causes joint pain, swelling, and stiffness. Target-specific DMARDs used to treat PsA include:4,7

  • Otezla® (apremilast)
  • Xeljanz® (tofacitinib)
  • Xeljanz XR® (tofacitinib)

Otezla is an oral systemic and phosphodiesterase 4 (PDE4) inhibitor. PDE4 inhibitors suppress parts of the immune response, such as cell recruitment and activation of inflammatory cells.4

Xeljanz and the extended-release version, Xeljanz XR, are Janus kinase (JAK) inhibitors. JAK is a type of cytokine or chemical messenger. It is believed to play a role in inflammation.6

Other drugs

There are several other drugs that may be used to treat PsA, including:1

  • Cyclosporine – one of the primary systemic drugs used to treat more severe types of psoriasis. It reduces or blocks certain immune system factors that cause inflammation in PsA. It is available under the brand names Sandimmune®, Neoral®, and Gengraf®.
  • Imuran® (azathioprine) – used to treat many autoimmune conditions. It works by suppressing the immune system.

Side effects of PsA treatment

Side effects can vary depending on the specific treatment or drug you are taking.

NSAID side effects may include:8

  • Upset stomach, diarrhea, and/or nausea
  • Indigestion
  • Headaches
  • Dizziness
  • Stomach ulcers

Corticosteroid side effects may include:3

  • Fluid retention
  • High blood pressure
  • Irritation or allergic reaction at the injection site
  • Weight gain
  • Mood changes
  • Insomnia
  • High blood sugar

Biologic side effects may include:9

  • Shortness of breath
  • Dizziness
  • Allergic reactions
  • Increased risk of infections

DMARD side effects may include:7

  • Headache
  • Irritation at the injection site
  • Hair loss
  • Tiredness or fatigue
  • Rash
  • Weight loss

These are not all the possible side effects of PsA drug treatments. Talk to your doctor about what to expect when taking these drugs. You also should call your doctor if you have any changes that concern you when taking these medicines.

Before beginning treatment for PsA, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you take. This includes over-the-counter drugs.

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