I'm sorry to hear that your doctor has been struggling to find a treatment that will bring you relief, . Unfortunately, because everybody's body reacts differently to medication, it can take some time to find a treatment that brings each individual person relief. You're definitely not alone. It's understandable that you're feeling frustrated after trying both Symponi and Orencia. That being said, there are luckily many more treatment options available to try, so please don't give up! I'm including a link here with more information on treatment options, https://psoriatic-arthritis.com/treatment. And don't hesitate to advocate for yourself with your doctor. Sending you gentle hugs! -- Warmly, Christine (Team Member)