I've been on Methotrexate and Humira for a year and a few months. I have suffered through acute nausea each weekend after my Methotrexate. I take Zofran and occasionally Phenergan for this and I usually feel better by the end of the day on Monday at the latest. Over the last 7 or 8 months, I've noticed a very heightened sense of smell to the point of extreme discomfort and of course my old pal, nausea. I've also developed a numbness in my left hand the last two fingers. Not pain, not tingling, actually numbness. It feels a bit like when you get a shot from the dentist, but its not all the way effective yet. This doesn't come and go. It is constant. It could be my imagination, but I swear its creeping into the side of my hand right below my fingers. I asked my doctor about it and she says neither of these things are symptoms of PSA. I have long suspected its the Methotrexate and she assures me its not that either. As a test, at her suggestion, I stopped the Methotrexate for two weeks and these really odd symptoms did not go away. She's referring to a neurologist and I'm back on the Methotrexate.
I'm unable to take NSAIDS and have found lower back pain and leg discomfort to be sometimes very difficult. Does anything work besides NSAIDS? My primary care doc is open to pain management options, but I have no idea what that would even be. Some days, I just don't feel well enough to even work and I have a job that has me sitting most of the time. I'm also having exhaustion. I feel like I'm falling apart here.