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Treatment Issues


  • By StefC

    I’m new here to the forum. I was just started on Otezla for my psoriatic arthritis and the nausea is brutal! Has anyone had good success with this med?

  • By kjb1971

    I was just diagnosed about 4 months ago and I am taking methotrexate. It is my understanding that a lot of these meds cause some stomach issues but do go away with time. Hopefully your medication will work for you. I know it can take up to 4 to 6 weeks to get the full benefit from your meds.

  • By Sean

    Right now, the way we attack autoimmune disorders was described by one rheumatologist in an article I read as, “Using a cannon to swat a fly.”

    I don’t know how many years down the road this will be but researchers are already looking into the metabolic component of diseases like RA and PsA and using that as a much more targeted means to fight them. In the future (hopefully near enough future for us all to benefit) that will mean we can switch off the PsA in a way that doesn’t affect the whole immune system.

    • By VickiN Moderator

      Sean, I am super interested in all the new developments surrounding targeted gene therapy. I totally agree, we need more specific approaches. Biologics are a great start, but they still knock out entire arms of the immune system (i.e. the inflammation arm), and that has widespread effects. Thanks for all your comments!
      -Victoria, Community Moderator

    • By Sean

      I asked my rheumatologist once about gene therapy and, while promising, she said you have to be careful because once you start unspooling genes you could start a cascade. So that could be far away. The metabolic therapies might be closer to fruition.

      But hopefully in the next 5-10 years something comes along that’s better than biologics. What gives me some hope is that that my mom was on a bilologic for her RA and it sent it into complete remission. When she got off the biologic (Remicade) her RA symptoms did not come back for many years. So I’m hopeful that maybe I’ll have the same response since she is my mother and all.

  • By Luke

    I have had psa for 15 years. I have tried most of the treatments out there. Simponi has been most effective. I was recently on Otezla for about 6 months it controlled my mild psoriasis but didn’t relieve much of my psa. It takes a while (up to 4 months) to get the full effect of otezla. It was hard on my stomach for about 2 weeks. The insomnia and the occasional headaches were intense. For what it costs I thought it would be much more effective. For now I’m sticking with Simponi. My best advice find a drug that works for you and stick with it.

  • By EINNA

    Having PsA for over 30 years I’ve experienced quite a number of treatments. I could not tolerate Otezla. I would be incapacitated for nearly 4 hours with profound nausea. I couldn’t tolerate losing 8 hours of my life a day. I didn’t have the chance to see if it helped ease the symptoms of my PsA because I discontinued quite soon after I began taking it.

  • By Robin

    I took Otezla for about 6 months with horrid results. I felt worse in every way, including my PsA. I have a cousin with PsA who has been on Otezla for 2+ years and is doing wonderfully. Everyone reacts differently. Best of luck!

  • By MaryCordts

    I was diagnosed with both Psoriatic Arthritis (mild) and Plaque Psoriasis (scalp is very thick and itchy.)
    One year ago, my blood work showed very high Eosinophil counts, indicating a lot of inflammation, cause unknown.
    Long story a little bit shorter, I went through many tests for cancer, etc., until it was narrowed down to inflammation from the above diseases.
    I started out with Cosentyx injections for 5 weeks, but had a bad reaction to it, because it severely suppressed my immune system. The drug’s manufacturer agreed with my doctors that I should give it up.
    Then, after a lot of research, I decided to try Otezla. I have been on it for 6 weeks, with no success. My scalp plaque has spread and thickened, and my joints on my fingers and elbows have gotten worse. I don’t know what to do.
    I don’t want to use any substance that has a cancer risk, but I feel stuck. Any ideas? Thanks.


    Hello I’ve been taking otezla for 5 months. Only side effects I think are migraines acid reflex. My skin has cleared about 75% still in pain from back to my feet. Lost

  • By studioartist

    Otezla was not helpful and just made me sick.