I've been taking Humira for the last four months and since before I started I also have been taking Prednisone and as long I'm taking the Prednisone the pain is almost to a minimum. About half through the Humira regimen I stopped taking Prednisone and after three days the pain started again, my doctor resumed the prednisone but at half the dose I was before, it has been almost a week since I stopped the prednisone again and some of the pain on my fingers, hip, ankles, shoulders, knees and toes has come back, not as bad as it did before but gradually has increased, next week I going take my next dose if the pain persist or increases I'll have to let the doctor know that is not working. One thing I found and I'm not sure if is related is that I the muscle behind my knee looks swollen, the doctor took some ultrasound images and it didn't find any tumor, it doesn't hurt but now I found another in my armpit and it has left me concerned.
If the medication isn't working, you should let your doctor know, but keep in mind that it takes months before the benefits can be seen.