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Changing biologics

I was diagnosed about 18 months ago with psa and fibro. I used Humira for a year with some breakthrough pain around 10 days. My insurance wouldn’t cover a weekly dose so my rheumy switched to Enbrel. I’ve had horrible pain the past few months. Not sure if it’s a fibro flare or from switching biologics. Does anyone have experience with switching? I figured since I was already on biologics I wouldn’t have any down time between. Thank you for your help.


Community Answers
  • Leanne Donaldson
    4 months ago

    Hello @danilyn555, well I have quite a bit of experience switching biologics. I am on my 6th one (I think I might have lost track now.) Anyway, from how I understand it, each biologic is targeted to work a little differently and therefore it takes time to build up in your system and make a difference. It depends on each medication,but in my experience, it takes about 3-5 doses to notice a difference. But that depends on the dosing schedule you are on. If you are still struggling with the switch check with your doctor. I hope you get some relief soon! -Leanne, Psoriatic-Arthritis.com Team

  • danilyn555 author
    4 months ago

    Thanks for your reply. I’ve been on a weekly dosage of the Enbrel (switched from Humira) for about 6 doses. I’ll probably call my doctor.

  • Leanne Donaldson
    4 months ago

    Oh yeah @danilyn555 6 doses in (in my opinion) would probably warrant a call to the doctor. They might want to do a round of steroids just to calm everything down. At least that’s what has been my experience in switching meds. It can feel like such a long time while you are waiting for some relief. -Leanne, Psoriatic-Arthritis.com Team

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