Hi! After being off the biologics for several weeks, I always flare up in my joints (usually my wrists, fingers, knees and ankles/feet); but I stay consistent using methotrexate every week. That seems to keep the flares from being too bad. I can handle the pain from the flare ups. After surgery I don’t seem to notice the flare up pain because the recovery from back fusions, shoulder or knee replacement is very painful as well as the PT.
It takes awhile, a couple of months, for another biologic to take affect.
The one biologic that worked the best for me was Enbrel and the Otezla comes in second.
I feel the Skyrizi is finally kicking in after the 2 starter doses and now on the second shot which I take every 8 weeks along with methotrexate.
I hope this information might help someone or relate to someone’s situation too.
Thank you again for the sincere correspondence!
Warmest regards to you as well. I hope you are doing well ♥️