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Can you be too sick for injections?

The doctor tells me that at this moment I can only "manage the pain." Because we have tried the first-line treatments (methotrexate and sulfasalazine) and I did not adapt well. "It's better, for now, not to go for injections" is the situation I've been in for almost a year. I have been following the Pain Unit. I take Pregabalin and Tramadol.

My question is: If I am sick to take Methotrexate or Sulfasalazine, why am I not (sufficiently) ill for other therapies?

  1. The right question is
    CAN YOU BE NOT TOO SICK FOR INJECTIONS (biologic therapies)?

    1. Next step is biologics to prevent permanent damage to your joints. MTX injections did not work for me; I tried Remicade (reacted poorly) then was on Humira for 5 years...it worked very well (until it worked TOO well, and I had to stop.). I am now on the loading doses of Cosentyx, hoping it will eventually resolve my current flare and work well for a number of years to control my PsA.

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