Hello I used to be on Simponi Aria and YES! I had the same experience when I was on it. So much so that I planned for it. I usually was very "tender" all over, kind of like I had the beginning of the flu. I always made sure to plan nothing for the 24 hours after I was due for an infusion. I'm not sure of the whole scientific reason, but I did learn that if I took Benedryl and tried to rest/sleep/binge watch through it, then it was okay. Once I started seeing results from the medicine, I decided that it was totally worth it for me. I wish you the best of luck with it and really hope it works for you. I'm sure others with experiences from our community will chime in soon. How are you doing today? Feeling a little better? -Leanne, Community Moderator