Thank you, Clair! Unfortunately, the Humira shot my blood pressure through the roof! I had to stop the Methotrexate and the Humira and get on Blood Pressure meds. Never had BP issues until I started treatment for the Psa. They agree it is because of the medications, I can't take the good anti-inflammatories. I just received Embrel and will begin taking that with a half dose weekly of the Methotrexate. It seems what ever they try either does not work or I have a reaction to it- so frustrating!