Skyrizzi

Hi Brenda, , I'm so glad you reached out. I hope some of our community members who've been on Skyrizi see your post here and can share their experiences and insights.

In the meantime, we do have a few community members who have posted about Skyrizi, so I wanted to share the links with you here. This one a member shared that Skyrizi was really helpful for them, https://psoriatic-arthritis.com/stories/symptoms. Some of the comments in this forum thread also mention Skyrizi, https://psoriatic-arthritis.com/forums/tnf-interleukin.

Is this something that you're considering trying for your PsA?

Please know that this community is here for you, and don't hesitate to reach out any time. Wishing you a gentle evening. -- Warmly, Christine (Team Member)

I've been on it since August, 2022, and it has worked great for me. But, I also eat a healthy diet, and exercise a lot. The only real side effects I've had on Skyrizi were during the loading dose phase, and consisted of a mild scalp fungal that was easily treated. Otherwise, I will occasionally get fatigued for a couple days after injecting, but nothing major. It has worked better than anything else I've been on over the years. Haven't had a major flare since starting it.

I've been on it now since September 2023 and it has been a real life changer for me. When I made the switch, I had less than 5 pounds of grip strength in each hand. In May of this year, I was up to almost 30 pounds in each hand and I've been able to start strength training again without fear of dropping a dumbbell on my head. I haven't had any real major side effects. I do get PMLE rash/sun sensitivity but I started getting that last summer before I ever started Skyrizi. It's not a known side effect. Fatigue is still an issue for a few days after injection so I do mine on the weekend.

Hi ! I've been on Skyrizi since August 2023 (so five doses total, including the two loading doses) with next dose in August.
I've not had any side effects at all, which was a big worry going in.
It's also made a big difference in my daily quality of life overall. What I call "resting pain" those aches in my joints even when I'm not actively using them, has diminished a great deal (with the exception of my back, but I have damage beyond PsA there), I don't get fatigued as easily, that morning stiffness isn't as bad and wears off faster, and I can do more before it starts to hurt than I could a year ago.
I do still have symptoms and I do still occasionally flare when I overdo it (like a recent state-to-state move), but the flares are less flattening and shorter.
The thing to remember is that Skyrizi is intended to stop further progression of the disease, so managing your expectations with regard to symptom relief is important. Eric has had tremendous results, coupled with diet and exercise. I don't have the ability to do the kind of exercise he does, so that might contribute to the slightly lesser symptom relief that I've had. But we're also all different and our bodies react differently.
Also, my psoriasis is completely gone, with the exception of one small spot in my left ear, but I'm going to have that looked at on my next Derm visit - it might not even be psoriasis.
Overall, I consider myself lucky to be on it. But I also have to laugh at myself sometimes too. About midway through the injection cycle, when I'm really at my best, I find myself thinking, "I feel okay. Maybe this is just all in my head." But when I get to the end of the cycle, about 7-10 days or so before the next injection, I feel that fatigue and joint pain creeping back in and it only gets better in the days after the injection. (Eric has mentioned he doesn't have that issue either.)
The actual injection pen is easy to use and doesn't hurt. The hardest things for me are to remember is that mental assessment to make sure there's nothing wrong going on in my body - they don't want you injecting at all if you have any signs of infection. And to list it on medications list at doctor's offices - I tend to forget since I don't take it daily like everything else, but it's important to include.
Hope this helps!