Hopefully some community members can chime in here too, but I thought you might find this article useful too:
https://psoriatic-arthritis.com/medications/biologics-how-well-works-side-effects
Are you currently on Enbrel, or perhaps thinking of starting? Thanks for reaching out to the community,
-Victoria, Community Moderator
I've used Enbrel on & off for over 20 years. It is the treatment that gives me the least side effects. I sometimes suffer from a headache the first day after the shot but that it is easily taken care of with ibuprofen. Once in a while I feel a little less my usual self, but it so worth the pain relief I experience while on Enbrel. Everyone is different. You need to find out what works for you.
I was on Enbrel for 18 months, I had extreme fatigue with enbrel and humira. I'm talking about the kind of fatigue where you fall asleep driving or just when you're sitting. Other than the fatigue I'd have a minor headache after taking the shots. I hope this helps!
I just started Enbrel 2 weeks ago and have had 2 shots. With in 24 to 48 hours of taking the drug, I felt extreme, knock you off your feet fatigue. So bad that I could my doctor and he has stopped me on the Enbrel and is going to prescribe me Humira. I am concerned the Humira will be the same. It did help my pain, but I can't handle the fatigue. I am also on methotrexate, which doesn't help with fatigue. I don't know if I had a reaction to the drug or not.
I felt that way on Methotrexate. I hated that medication. The worse fatigue ever all I wanted to do was sleep.
Enbrel was one of the first drugs I was prescribed about 20 years ago. At first it was the answer to my prayers. It cleared my skin entirely and I felt like mold self again. Actually better than my old self. Eventually it stopped controlling my symptoms and it would cause swelling and huge black and blues where I injected it so I was switched to Humira. Up until recently Humira has been my life saver. Recently because of insurance issues I was switched to Simlandi. I've only been on Simlandi for about 2 months and so far I don't notice a difference from Humira.
