I'm beginning Orencia infusions on Wednesday and wondered if anyone here can give me insight on what to expect. I've been on methotrexate for 6 months for psoriasis and rheumatologist upped from 4 to 6 but this is my first biologic. Have others had any relief for PsA and inflammatory polyarthritis with Orencia? I have multiple heart conditions and COPD so tnf inhibitors are absolutely out. Can anyone share their experience? I'm nervous and a bit afraid but any relief will be amazing. Thanks in advance.