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In the last 2-3 weeks, I have developed 5 fingernails (3 on the left and 2 on the right), lifting and becoming hard/brittle. I am currently on Tremfya (this is the 5th biologic I've been on) and have had "success" with my pain levels for 5-6 out of the 8-week dosage. I've been on it for a little over 2 years. Is this newish nail symptom (I've never had this many or this bad before) a possible sign that the Tremfya is not working as well anymore? I do have to admit that I have been having more intense pain in my joints when it breaks through my pain meds. Please advise as much as you can, as I really don't want to have to try a new medication!