Sorry nobody chimed in to share a similar experience, . You're not alone in cycling through medications, it's something many people in our community talk about. It takes a painfully long time for some people to find "The One." Our longtime contributor Leanne wrote about number five here, Fifth Time’s the Charm.
I get why you're concerned about unrelenting ankle pain, new psoriasis, and the interruption of your menstrual cycle. It's all so frustrating! Bottom line is, it's important to share the ways you're reacting to a new medication with the prescribing doctor — not only so they can monitor your progress and make adjustments, but also watch for unwanted side effects.
Have you let your medical team know how you're feeling? If not, I hope you will; you shouldn't have to live in so much pain and discomfort. Hugs. -Eileen, Psoriatic-Arthritis.com Team