I have been on a combination of Otezla and Remicade with methotrexate and then Otezla, Cosyntex and methotrexate and most recently otezla, Tremfya and methotrexate. During this time I have continued to have worsening and enthesitis and bony distruction and pain and debility. I was hoping to find out if there had been anyone else out there with combination therapy aside from these that has found it has worked or has other suggestions. I’m hoping to speak with a rheumatologist about combining Stelara, Enbrel and Cosyntex as another possibility at this point. I am feeling desperate and any help that anyone can provide would be amazing thank you