I am waiting for insurance approval for Taltz. I have tried Enbrel, it worked well for a couple of years. Then Humeria until the cardiac issues. My new Rheum thinks I had an episode of Humeria induced Lupus. The Otezla for about a year. That worked a little for about 9 months the the flares started. I have used 2 doses of Stelara. That cleared my skin but has done nothing for my joints. I hope Taltz will help.