For the most part. Personally, you would have too look at my hands closely to see it or see me get up from a chair after sitting a bit to notice. I'm active and eat cleanly so I look rather healthy. However, it takes me a good hour at my computer in the morning with my coffee after I peel myself out of bed to feel like moving more and I don't do anything in the evenings because I'm too tired and brain dead ! I try real hard, exercise & stretch daily and take a Humiro biosimilar but I'm still in some pain and wear wrist braces a lot and good shoes.