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Bloodwork for PsA: What Do the Results Mean?

There is no single test to diagnose psoriatic arthritis (PsA). Reaching a diagnosis of PsA is a process that includes a physical exam, patient history, imaging scans, biopsies, and blood tests. PsA can look similar to other inflammatory conditions, so doctors will often use blood tests to get a closer look at what might be causing your symptoms.1

Testing for Anti-CCP or rheumatoid factor

Some symptoms of PsA look very similar to rheumatoid arthritis (RA). Your doctor may test for antibodies to cyclic citrullinated peptides (anti-CCPs), also known as rheumatoid factor. The presence of rheumatoid factor in the blood means that the patient’s immune system is attacking the body, which can lead to inflammatory symptoms that are common in RA.2,3 Still, patients with PsA may also test positive for anti-CCP.4

Testing levels of C-reactive protein and erythrocyte sedimentation rate

Your doctor may also test your blood to measure the level of c-reactive protein (CRP) or erythrocyte sedimentation rate (ESR)—the higher the level of CRP or ESR, the more inflammation in the body. CRP and ESR are only higher in about half of patients with PsA. These tests are also useful to predict the progression of disease.2,3

Testing for uric acid

Another test used to mainly rule out another condition similar to PsA is a uric acid test. Uric acid tests are often used to diagnose gout. Patients with gout typically have a build-up of uric acid in the joints and surrounding tissues, which can form crystals that cause swelling and pain. Some doctors may continue to repeat uric acid tests after you have been diagnosed with PsA. There is some evidence that there could be a connection between gout and PsA when it comes to uric acid. Studies have shown that the inflammation experienced in PsA can cause uric acid to build up, which can increase the risk of gout down the road.5

Blood tests to monitor liver enzyme levels

Certain treatments available for PsA also require ongoing blood test monitoring. Your doctor may prescribe a disease-modifying antirheumatic drug (DMARD) to treat PsA. DMARDs work by blocking chemicals that cause inflammation in the body, therefore preventing joint damage and reducing pain and discomfort. DMARDs include medications such as methotrexate, sulfasalazine, cyclosporine, and leflunomide, as well as a newer class of DMARDs known as biologics. DMARDs can increase your risk for liver damage, so your doctor may choose to monitor your liver enzyme levels if you are prescribed any of these medications.6,7

Routine blood monitoring with biologics treatments

While biologic DMARDs can be very effective at slowing joint damage progression and treating the symptoms of PsA, they also suppress the immune system, which can increase the likelihood of infection. If you are prescribed a biologic to treat your PsA, in addition to liver enzyme testing, your doctor will likely monitor you for tuberculosis and take frequent complete blood count (CBC) panels to assess your risk of infection. Depending on which biologic you are prescribed, additional monitoring may be required.8

What if your bloodwork is normal?

Often patients with PsA will have normal CRP and ESR levels. Similarly, while anti-CCP is typically an RA indicator, anti-CCP can be both negative or positive in PsA. While bloodwork is certainly part of the diagnostic process, patient history and a physical examination are the most important factors to correctly diagnose PsA.4,9

  1. National Psoriasis Foundation. About psoriatic arthritis. Accessed May 10, 2018.
  2. Punzi L, Podswiadek M, Oliviero F, et al. Laboratory findings in psoriatic arthritis. Reumatismo.2007;59(Suppl 1):52-5.
  3. Rheumatoid Arthritis Support Network. Anti-CCP Test (Anti-cyclic Citrullinated Peptide). Accessed May 10, 2018.
  4. Inanc, N., Dalkilic, E., Kamali, S. et al. Clin Rheumatol (2007) 26: 17. Accessed May 10, 2018.
  5. Arthritis Foundation. Psoriasis and psoriatic arthritis linked to increased gout risk. Accessed May 8, 1018.
  6. Arthritis Foundation. Psoriatic arthritis treatment. Accessed May 10, 2018.
  7. Curtis JR, Beukelman T, Onofrei A, et al. Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide. Ann Rheum Dis. 2910;69(1):43-7.
  8. Arthritis Foundation. Biologics: Monitoring. Accessed May 10, 2018.
  9. Birtane M, Yavuz S, Tastkkin N. Laboratory evaluation in rheumatic diseases. World J Methodol. 2017;7(1):1-8.


  • leigh
    1 year ago

    i too have problems when i am in a flare that it never shows on my blood tests. Even the doctors look at me as if im putting it on, why would i do that. The pain is too much to take sometimes and the meds dont help much either. I hope you manage to get some let up in your pain soon.

  • Jaime Lyn Moy
    1 year ago

    Both my son and I have PsA. He was 5 when diagnosed and now has joint damage in his hands and toes and his hip is fused where it shouldn’t be. His disease severity is worse than mine, but neither of us have shown elevated sed rates or other indications of PsA, even when in a big flare. We know how we feel and how much pain we’re in, but it doesn’t equate to numbers in a lab. That just makes this disease so much more frustrating.

  • bdmc
    1 year ago

    Yes, hard to wrap my brain around it. Perfectly normal blood work even when I’m feeling worse than ever.

  • mich54
    1 year ago

    I am the same way Jamie. My blood work does not show my inflammation and it is so frustrating. My body is full of it – in many places – but yet it doesn’t show in the blood. I just don’t get it.

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