MJk2011 and VickiN....... Ok so my thing is I feel I am constantly in a flair then. I guess, basically, everyone is different. I read the articles on it. I guess I am questioning if others have stiffness/soreness all the time? That is my issue. I have it all the time. It never goes away. I have had some times when something will flair....ie, my wrist swelled, my finger, my ankle.... or just times when one part might hurt extra for some days at a time. But as for the day to day living, It never goes away. I wake up very stiff.... I can move a little easier after a while, but if I sit for a while, I am definitely more stiff. Or if I overexert myself (shopping, cleaning, etc.) I feel more stiff and more fatigued. I am constantly fatigued anyway. I have to pace myself and traveling is hard because it just takes so much out of me and you can't pace yourself so well when you travel. I just started Humira (actually yesterday was my 2nd injection). I feel no difference yet and I am depressed thinking nothing is ever going to help me. I have been dealing with this for 30 years, with it continually getting worse and worse. (I didn't get a true diagnosis until just maybe 6/8 months ago.....I have gone all these years with no one seeming to put the puzzle together, until I finally did it myself.) I even had pushed for parathyroid surgery in 2010 thinking that could be my problem. Crazy..... all these years, and no one helped me. I think I even ended up with a heart blockage in 2007 because of this. I am just feeling depressed that maybe this isn't going to help me either.